INTERLEUKIN-10 ENHANCES THE OXIDIZED LDL-INDUCED FOAM CELL FORMATION OF MACROPHAGES BY ANTIAPOPTOTIC MECHANISMS

Interleukin-10 enhances the oxidized LDL-induced foam cell formation of macrophages by antiapoptotic mechanisms

Interleukin (IL)-10 may have a therapeutic potential in atherosclerosis, but its mechanisms of action have not been clarified.Foam cell formation is a key event in atherogenesis, and apoptosis of these lipid-laden cells may promote plaque destabilization.We sought to explore whether IL-10 Sexual Wellness could have plaque-stabilizing properties in

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Modulation of macrophage activation state protects tissue from necrosis during critical limb ischemia in thrombospondin-1-deficient mice.

BackgroundMacrophages, key regulators of healing/regeneration processes, strongly infiltrate ischemic tissues from patients suffering from critical limb ischemia (CLI).However pro-inflammatory markers correlate with disease progression and risk of amputation, suggesting that modulating macrophage activation state might be beneficial.We previously r

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